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Subsequently, he has investigated small molecules

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His lab was the first to discover a defect in the TDP 43 gene, a novel cause of MND. This discovery led to the development of a diagnostic test which is in use in the clinic today. Subsequently, he has investigated small molecules that bind to abnormal TDP 43; firstly, as potential imaging agents and secondly as drugs that may slow down or stop the build up of misfolded proteins within neurons.

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